Figure 1.

Mean plasma concentration-time profiles of CsA. On day 1, the rats received a single oral dose of CsA (10 mg/kg) alone. From days 3 to 8, all rats assigned to the Que-treatment groups were gavaged with 25, 50 or 100 mg/kg/day of Que for 6 consecutive days. On day 9, animals were pretreated with the relevant dosage of Que 0.5 h prior to the final dose of CsA (10 mg/kg), and blood samples were collected at various time points for pharmacokinetic analysis. Data are presented as the mean ± standard deviation for each data point (Que-treated groups, n=8; CsA alone group, n=24). CsA, cyclosporine; Que, quercetin.