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. 2016 Aug 24;14(4):3646–3654. doi: 10.3892/mmr.2016.5670

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Copyright: © Shen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Resveratrol upregulates the protein expression levels of Nrf-2 in the nuclei, and NQO-1 and HO-1 in the cytoplasm of neural stem cells following oxygen-glucose deprivation/reoxygenation injury in vitro. (A) Protein expression of Nrf2 in nuclei and NQO-1 and HO-1 in cytoplasm. Quantification of data for (B) Nrf2, (C) NQO-1 and (D) HO-1. Western blot analysis revealed that the protein expression levels of Nrf2 in the nuclei, and NQO-1 and HO-1 in the cytoplasm were significantly upregulated in the Mod and Res groups, compared with those in the Nor group. The levels were highest in the 5 μmol/l resveratrol (Res5) group suggesting resveratrol increased expression of Nrf2 in the nuclei and NQO-1 and HO-1 in the cytoplasm. ^▲P<0.05, vs. Nor group; ^ΔP<0.05, vs. Mod group. Data are presented as the mean ± standard deviation and were compared using one-way analysis of variance (n=3 for each group). Nor, normal; Mod, model; Res, resveratrol; Nfr-2, nuclear factor erythroid 2-related factor 2; NQO-1 NAD(P)H:quinone oxidoreductase 1; HO-1, heme oxygenase 1.