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. 2016 Aug 24;14(4):3535–3542. doi: 10.3892/mmr.2016.5669

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Copyright: © Hu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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ARC overexpression in human osteoblasts by stable transduction and it can enhance survival of human osteoblasts. (A) The fluorescence microscopy detection of enhanced green fluorescent protein-positive human osteoblasts on day 3 subsequent to lentiviral infection (magnification, ×100). (B) ARC mRNA and (C) protein expression levels were increased significantly in ARC-overexpressed cells compared with control cells. ^****P<0.0001 vs. control group. (D) Cell numbers [as measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay] were significantly higher in ARC-overexpressed human osteoblasts compared with empty vector-transfected controls under 0, 1 and 5 µM concentrations of Zoledronate. ^*P<0.05, ^**P<0.01, ^***P<0.001, ^****P<0.0001 vs. empty vector-transfected control groups. ARC, apoptosis repressor with caspase recruitment domain; OB, osteoblast; con, control; nol, Zoledronate.