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. 2016 Sep 28;68(10):2492–2502. doi: 10.1002/art.39706

Figure 2.

Figure 2

ANA‐positive healthy individuals have higher levels of certain proinflammatory soluble mediators seen in SLE patients and elevated levels of the regulatory cytokine IL‐1Ra. Proinflammatory soluble mediators were measured by multiplex assay or enzyme‐linked immunosorbent assay and included TNF (A), IFNγ (B), IL‐10 (C), IL‐1α (D), IP‐10 (E), IL‐2 (F), IL‐12p70 (G), IL‐4 (H), and IL‐17A (I). Soluble mediators differently regulated in SLE included IFNα (J), IFNβ (K), BLyS (L), IL‐12p40 (M), stem cell factor (SCF) (N), IL‐1Ra (O), and IL‐1Ra:IL‐1β ratio (P). Each data point represents an individual subject; horizontal lines show the median and interquartile range. ∗ = P < 0.05; ∗∗ = P < 0.01; ∗∗∗ = P < 0.001; ∗∗∗∗ = P < 0.0001 by Kruskal‐Wallis test followed by Dunn's multiple comparison test. FI = fluorescence intensity; NS = not significant (see Figure 1 for other definitions).