Table 1.
Demographics and GI, psychological, and quality of life measures
| IBS (n=272) | Non-FGID (n=246) | p-value | |
|---|---|---|---|
| Demographics | |||
| Age (yrs) | 47.6 ±0.9 | 51.6 ± 1.0 | 0.003 |
| Female sex (%) | 221 (81) | 161 (65) | <0.001 |
| GI Symptoms | |||
| Bowel symptom bother (VAS) | 6.9 ± 0.2 | 4.1 ± 0.2 | <0.001 |
| Bowel symptom severity (VAS) | 6.9 ± 0.2 | 4.0 ± 0.2 | <0.001 |
| Bowel symptom frequency (days/last 2 wk) | 9.0 ± 0.3 | 5.2 ± 0.4 | <0.001 |
| GSRS-IBS | |||
| Pain subscale | 7.8 ± 0.2 | 4.5 ±0.2 | <0.001 |
| Bloating subscale | 10.3 ±0.3 | 6.4 ± 0.3 | <0.001 |
| Constipation subscale | 5.7 ±0.2 | 3.6 ±0.2 | <0.001 |
| Diarrhea subscale | 12.6 ±0.4 | 8.2 ±0.4 | <0.001 |
| Psychological measures (continuous) | |||
| Beck depression inventory [BDI] | 12.3 ± 0.6 | 7.8 ± 0.5 | <0.001 |
| Beck anxiety inventory [BAI] | 13.2 ±0.6 | 8.1 ±0.6 | <0.001 |
| Patient-Health Questionnaire-15 [PHQ-15] | 13.0 ± 0.3 | 9.4 ± 0.5 | <0.001 |
| Patient-Health Questionnaire-12 [PHQ-12]* | 8.5 ± 0.3 | 6.7 ± 0.4 | <0.001 |
| Psychological measures (dichotomous) | |||
| Depression [BDI ≥20] (%) | 59 (22) | 26 (11) | 0.001 |
| Anxiety [BAI ≥16] (%) | 85 (31) | 34 (14) | <0.001 |
| Somatic Symptoms [PHQ-15 ≥15] (%) | 82 (30) | 30 (12) | <0.001 |
| Quality of life measures | |||
| SF-36 Total | 50.4 ± 1.4 | 63.8 ± 1.6 | <0.001 |
| SF-36 Physical | 44.5 ± 1.4 | 58.9 ± 1.7 | <0.001 |
| SF-36 Mental | 51.8 ± 1.5 | 63.5 ± 1.6 | <0.001 |
*
PHQ-12(26) questionnaire excludes three GI symptoms (“stomach pain,” “constipation, loose bowels, or diarrhea,” and “nausea, gas, or indigestion”) from the PHQ-15.