Table 2.

Overview of novel and known BP variant properties.

	17 new loci	49 established loci	66 loci
Minor allele frequency (mean, range)	32.1% [5%-50%]	28.9% [7%-49%]	29.8% [5%-50%]
Effect size SBP [mmHg] (range, mean)	0.09-0.59, 0.34	0.07-1.13, 0.5	0.07-1.13, 0.46
Effect size DBP [mmHg] (range, mean)	0.1-0.46, 0.23	0.06-0.60, 0.3	0.06-0.6, 0.28
Variance explained SBP	0.52%	2.95%	3.46%
Variance explained DBP	0.58%	2.78%	3.36%

Key characteristics of the novel and established BP loci are shown. MAF and effect size estimates are derived from the Cardio-MetaboChip data. Variance explained estimates are estimated from one large study (Supplementary Note). Novel loci are classified as previously unknown to be linked to BP by a systematic PubMed review of all genes in a 200kb window (Supplementary Note).