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. 2016 Aug 9;59(11):2448–2458. doi: 10.1007/s00125-016-4067-4

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Expression of NLRC5 in the islets of control individuals and those with type 1 diabetes. (a) Representative islets from an individual without diabetes and a patient with type 1 diabetes are shown (red, HLA-ABC; green, NLRC5; light blue, insulin; dark blue, DAPI). Scale bar, 25 μm. (b) MFI values for NLRC5 protein expression were quantified after immunostaining in five islets per section from four control and four type 1 diabetes (three from the UK, one from nPOD) samples (p = 0.0704). (c) Expression of NLRC5 was compared in RNA isolated from islets of individuals with and without type 1 diabetes (p = 0.4504)