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. Author manuscript; available in PMC: 2017 Sep 28.
Published in final edited form as: J Am Chem Soc. 2016 Sep 16;138(38):12678–12689. doi: 10.1021/jacs.6b08610

Table 1.

Binding of pentalenolactone F (2) and 6,7-dihydropentalenolactone F (7) to wild-type PntM and mutants.

Protein KD (μM) Protein KD (μM)

PntM - wt 7.2±0.8 (2) PntM - wt 170±17 (7)
PntM-F232A 270±85 (2) PntM-M81A 340±90 (2)
PntM-F232G 225±45 (2) PntM-M81C 43±3 (2)
PntM-F232L 160±12 (2) PntM-M77S 115±8 (2)
PntM-M81C-BME 31±1 (2)