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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Mol Psychiatry. 2016 Mar 29;22(2):296–305. doi: 10.1038/mp.2016.33

Figure 2. Gene pathways changed by riluzole in aged rats are similar and in the opposite direction to those changed in post-mortem AD brains.

Figure 2

A. Schematic representation of the bioinformatics strategy used to generate pathway lists. Only genes significantly differentially expressed in at least two studies were included. B. Significantly enriched pathways derived from genes upregulated by riluzole (light green bars) were similar to gene pathways downregulated in AD brains (dark green bars). Gene pathways downregulated by riluzole (light blue bars) also showed similarity to pathways that are increased in AD (dark blue bars). Differentially expressed gene lists from AD brains were derived from publically available data posted in GEO and AMP-AD and subjected to pathway analysis using DAVID. (Enrichment score >1.3 reflects p<0.05)