Table 2.
Age-standardized death rates per 1000 (with 95 % confidence intervals) for patients treated with typical and/or atypical antipsychotics or clozapine and individuals from the general population
| Group | Women | Men | Total |
|---|---|---|---|
| 2008–2012 | |||
| Only atypical agents | 39.06 (34.79–43.33) | 62.92 (56.6–69.17) | 48.38 (44.78–51.98) |
| Atypical + typical agents | 42.82 (39.83–45.8) | 68.4 (64.34–72.45) | 53.25 (50.8–55.69) |
| Clozapine | 53.5 (45.69–61.32) | 79.2 (69.29–89.11) | 65.11 (58.63–71.58) |
| Only typical agents | 49.51 (46.0–52.03) | 94.68 (91.65–97.71) | 69.6 (67.64–71.56) |
| General population | 5.42 (5.37–5.47) | 10.12 (10.04–10.21) | 7.48 (7.43–7.53) |
| 2008 | |||
| Only atypical agents | 68.17 (61.25–75.1) | 98.78 (88.22–109.34) | 79.21 (73.31–85.11) |
| Atypical + typical agents | 72.45 (66.82–78.1) | 102.98 (95.32–110.65) | 84.33 (79.78–88.88) |
| Clozapine | 85.01 (70.83–99.18) | 113.99 (98.17–129.82) | 95.57 (85.28–105.87) |
| Only typical agents | 71.56 (67.2–75.91) | 126.31 (121.21–131.4) | 94.44 (91.16–97.73) |
| General population | 5.79 (5.66–5.91) | 10.77 (10.56–10.97) | 7.95 (7.84–8.06) |
| 2009 | |||
| Only atypical agents | 55.04 (49.77–60.31) | 83.5 (74.77–92.23) | 65.32 (60.57–70.08) |
| Atypical + typical agents | 58.66 (54.14–63.18) | 92.17 (85.6–98.73) | 71.45 (67.65–75.24) |
| Clozapine | 62.99 (51.68–74.3) | 97.65 (82.37–112.92) | 78.07 (68.25–87.88) |
| Only typical agents | 59.91 (55.56–64.27) | 103.56 (98.77–108.35) | 77.45 (74.29–80.61) |
| General population | 5.62 (55.01–57.4) | 10.56 (10.36–10.76) | 7.76 (7.65–7.87) |
| 2010 | |||
| Only atypical agents | 45.25 (40.66–49.85) | 70.61 (63.07–78.15) | 54.99 (50.81–59.16) |
| Atypical + typical agents | 45.73 (41.98–49.48) | 73.8 (67.92–79.68) | 57.18 (53.78–60.59) |
| Clozapine | 48.17 (39.19–57.15) | 70.97 (58.03–83.92) | 58.57 (50.56–66.57) |
| Only typical agents | 45.55 (42.6–48.85) | 83.68 (79.33–88.04) | 61.48 (58.74–64.22) |
| General population | 5.26 (5.15–5.37) | 9.96 (9.77–10.15) | 7.32 (7.22–7.43) |
| 2011 | |||
| Only atypical agents | 22.22 (19.14–25.3) | 32.49 (27.41–37.56) | 26.13 (23.43–28.83) |
| Atypical + typical agents | 24.42 (21.57–27.27) | 37.31 (33.06–41.57) | 29.51 (27.12–31.91) |
| Clozapine | 27.67 (19.5–35.85) | 36.19 (27.1–46.48) | 31.08 (24.99–37.17) |
| Only typical agents | 20.6 (18.4–22.8) | 34.52 (31.36–37.69) | 26.95 (24.95–28.95) |
| General population | 5.15 (5.04–5.27) | 9.57 (9.39–9.76) | 7.1 (6.99–7.2) |
| 2012 | |||
| Only atypical agents | 16.2 (13.77–18.62) | 29.61 (24.71–34.51) | 25.36 (22.46–28.27) |
| Atypical + typical agents | 17.41 (15.13–19.7) | 30.46 (26.47–34.44) | 26.89 (24.43–29.35) |
| Clozapine | 22.29 (15.63–29) | 24.81 (16.39–33.23) | 25.98 (20.35–31.61) |
| Only typical agents | 23.57 (20.15–27) | 40.49 (37.17–43.82) | 27.85 (25.91–29.79) |
| General population | 5.32 (5.21–5.43) | 9.86 (9.68–10.05) | 7.32 (7.22–7.42) |