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. 2016 Jul 20;90(10):2531–2562. doi: 10.1007/s00204-016-1798-4

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Male and female rat feed efficiency in the 1-year feeding trial. Line plots of mean feed efficiency per cage (g) and per week (weeks 1–13) or per 2 weeks (weeks 15–53) in the case of male (a) and female rats (b)