Table 10.

Gross necropsy observations and histopathological findings in female Wistar Han RCC rats fed the control or 33 % GMO diet for 1 year

Group	Animal no.	Gross necropsy observations	Histopathological findings
Control	141	None	No histopathological alterations
	142	None	No histopathological alterations
	143	Cystic formation in the right ovary	Follicular cysts in the right ovary
	144	Bilateral petechial haemorrhage (site: submandibular lymph node), hyperaemic pituitary gland, maxilla deformation, thickened skin area	Cutaneous papilloma, cystic endometrial hyperplasia
	145	Cystic formation in the right ovary	Follicular cysts in the right ovary
	146	Cystic formation in the left and right ovary	Follicular cysts in the left and right ovary
	147	Bilateral hyperaemic submandibular lymph node	Cysts in the thymus, no further histopathological alterations
	148	None	Follicular cysts in the left ovary
	149	None	Tubular dilation and atrophy in the right kidney
	150	None	No histopathological alterations
	151	None	Focal interstitial nephritis in the rat kidney
	152	None	No histopathological alterations
	153	Hyperaemic right submandibular lymph node, petechiae on the left submandibular lymph node, cystic formation in the left and right ovary	Tubular dilation and atrophy in the right kidney, no further histopathological alterations
	154	Bilateral petechial haemorrhage (submandibular lymph node)	No histopathological alterations
	155	None	No histopathological alterations
	156	Diaphragmatic hernia	Diaphragm sample not analysed
	157	Light brown-coloured mass of adipose tissue on the right side of the abdominal cavity	Lipoma
	158	Thickened right horn of the uterus	Cystic endometrial hyperplasia, focal hyperplasia/zona fasciculata in the right adrenal gland
	159	Mammary gland abscess, bilateral petechial haemorrhage (submandibular lymph node)	Mammary gland comedocarcinoma
	160	None	No histopathological alterations

Group	Animal no.	Gross necropsy observations	Histopathological findings
33 % GMO	101	Cystic formation in the right ovary	Follicular cysts in the right ovary
	102	Light brown coloured mass in the epigastrium	Lipoma
	103	Bilateral petechial haemorrhage (site: submandibular lymph node), atrophy of the left and right ovary	Lack of secondary and tertiary follicles in the left and right ovary; no further histopathological alterations
	104	Hyperaemic, dark coloured submandibular lymph node	No histopathological alterations
	105	Hyperaemic pituitary gland	No histopathological alterations
	106	Cystic formation in the left and right ovary	Follicular cysts in the left and right ovary
	107	Superficially damaged skin surface	Skin sample not analysed
	108	None	No histopathological alterations
	109	Cystic formation in the left and right ovary	Follicular cysts in the left and right ovary
	110	Bilateral hyperaemia in the submandibular lymph node, cystic formation in the left and right ovary	Follicular cysts in the left and right ovary
	111	Bilateral hyperaemia in the submandibular lymph node	Endometrial stromal hyperplasia; no further no histopathological alterations
	112	Damaged skin surface	Focal hyperkeratosis, spongiosis, acanthosis, granulation tissue, hypertrophy of the sebaceous glands and follicular dysplasia (site: skin); follicular cysts in the rat ovary
	113	Bilateral hyperaemia in the submandibular lymph node	No histopathological alterations
	114	Bilateral hyperaemia in the submandibular lymph node	No histopathological alterations
	115	None	Lymphoepithelioid granuloma in the small intestine
	116	Bilateral petechial haemorrhage (site: submandibular lymph node)	Tubular dilation and atrophy in the left kidney, no further histopathological alterations
	117	Cystic formation in the left ovary	Follicular cysts in the left ovary, lymphoepithelioid granuloma in the small intestine, cysts in the pituitary gland
	118	Bilateral petechial haemorrhage (site: submandibular lymph node)	No histopathological alterations
	119	None	No histopathological alterations
	120	None	No histopathological alterations