. 2016 Jul 20;90(10):2531–2562. doi: 10.1007/s00204-016-1798-4

Table 3.

Clinical observations in male and female Wistar Han RCC rats during the 1-year feeding trial

Group	Animal no.	Week no.	Clinical observations
Male rats
33 % GMO	2	10	Diarrhoea
	7	25	Bite wounds on the left scapula and left ventral side
	15^a	31	Paraplegia of the hind limbs
Control	50	6	Diarrhoea
Conventional 2	63	9	Diffuse epistaxis, chromodacryorrhea
Conventional 2	79	40	Exophthalmos (both eyes), diarrhea
Female rats
33 % GMO	102	43	Chromodacryorrhea
	106	25	Hair loss between the scapulae
	107	23–53	Bite wound, pruritus and scabs between the scapulae
	109	26	Tail wound
11 % GMO	126	30	Bite wound between the scapulae
	129	42–53	Hair loss on the left side of the face
	131^a	33–34	Weight loss, apathy, piloerection, hypersalivation, haematemesis, chromodacryorrhea, enlarged abdominal cavity, abdominalgia, dyspnoea
	135	26	Tail wound
Control	144	42–53	Maxilla deformation, exophthalmos, chromodacryorrhea, dyspnoea
	147	9	Bite wound on the back
	159^a	31–47	Mammary gland abscess

^aRats 15, 131 and 159 were killed on days 227, 244 and 327, respectively