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. 2016 Jul 20;90(10):2531–2562. doi: 10.1007/s00204-016-1798-4

Table 4.

Mean values ± standard deviations (SD) of haematology parameters in male and female Wistar Han RCC rats at 3, 6 and 12 months

Parameter Males Females
Control1 Conv. 22 11 % GMO3 33 % GMO4 Control5 Conv. 26 11 % GMO7 33 % GMO8
At 3 months
 WBC (103/μl) 7.16 ± 0.83 6.44 ± 0.94 8.24 ± 1.89 7.71 ± 1.39 5.16 ± 1.45 6.65 ± 1.23 5.65 ± 1.58 6.71 ± 1.39
 RBC (106/μl) 8.12 ± 0.22 8.26 ± 0.34 7.98 ± 0.51 8.14 ± 0.39 7.71 ± 0.24 8.07 ± 0.25 7.27 ± 0.43 7.41 ± 0.43
 HGB (g/dl) 16.09 ± 0.34 15.94 ± 0.72 16.05 ± 0.62 16.12 ± 0.74 15.15 ± 0.93 15.64 ± 0.38 14.83 ± 0.97 14.99 ± 0.81
 HCT (%) 44.90 ± 1.17 45.11 ± 2.40 43.87 ± 2.85 45.25 ± 2.37 43.72 ± 1.46 45.04 ± 1.09 41.69 ± 2.40 41.71 ± 1.97
 MCV (fl) 55.32 ± 0.89 54.64 ± 1.47 54.91 ± 0.65 55.68 ± 1.03 56.74 ± 1.16 55.84 ± 1.28 57.39 ± 0.39 56.34 ± 0.95
 MCH (pg) 19.86 ± 0.44 19.32 ± 0.41 20.17 ± 1.07 19.85 ± 0.36 18.20 ± 4.24 19.39 ± 0.56 20.42 ± 0.75 20.26 ± 0.27
 MCHC (g/dl) 35.94 ± 0.48 35.35 ± 0.39 36.79 ± 2.30 35.64 ± 0.43 31.93 ± 7.30 34.73 ± 0.51 35.59 ± 1.12 35.95 ± 0.34
 PLT (103/μl) 678.00 ± 140.75 717.70 ± 34.10 766.90 ± 112.28 748.60 ± 143.33 699.40 ± 203.54 723.70 ± 99.60 656.50 ± 110.51 655.70 ± 114.11
 LYM (103/µl) 4.93 ± 0.82 4.42 ± 0.68 5.87 ± 1.33 5.95 ± 1.30 3.31 ± 0.84 4.40 ± 0.78 3.76 ± 1.01 4.42 ± 1.04
 Lymphocytes (%) 71.00 ± 4.51 68.10 ± 5.39 70.80 ± 4.83 73.70 ± 3.51 70.45 ± 4.01 67.65 ± 4.79 69.85 ± 3.26 69.35 ± 6.89
 Neutrophils (%) 23.90 ± 4.21 26.00 ± 3.81 23.85 ± 5.36 21.70 ± 2.72 25.00 ± 4.05 26.55 ± 4.02 24.60 ± 2.58 24.60 ± 6.09
 Monocytes (%) 2.75 ± 0.64 4.10 ± 3.16 2.25 ± 0.59 3.05 ± 1.02 2.65 ± 0.63 3.20 ± 0.45 2.75 ± 0.61 2.35 ± 0.84
 Eosinophils (%) 2.35 ± 0.89 1.80 ± 0.97 3.10 ± 1.59 1.55 ± 0.48 1.85 ± 0.52 2.55 ± 1.14 2.80 ± 0.93 3.65 ± 0.96a,c
 Basophils (%) 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.05 ± 0.11 0.05 ± 0.11 0.00 ± 0.00 0.05 ± 0.11
At 6 months
 WBC (103/μl) 7.06 ± 0.57 8.44 ± 2.09 8.48 ± 0.63b,c 9.10 ± 1.49c 6.06 ± 1.36 7.85 ± 0.87b 7.05 ± 1.44 7.02 ± 1.00
 RBC (106/μl) 8.34 ± 0.18 8.28 ± 0.16 8.07 ± 0.20 8.21 ± 0.25 7.69 ± 0.23 7.72 ± 0.42 7.36 ± 0.25 7.56 ± 0.44
 HGB (g/dl) 16.13 ± 0.54 15.83 ± 0.46 15.39 ± 0.55 15.94 ± 0.52 15.55 ± 0.27 15.29 ± 0.50 15.23 ± 0.37 15.40 ± 0.65
 HCT (%) 46.29 ± 1.29 45.62 ± 1.40 44.49 ± 1.41 45.48 ± 1.30 44.85 ± 0.95 44.16 ± 1.67 43.23 ± 1.10 43.69 ± 1.93
 MCV (fl) 55.53 ± 1.26 55.10 ± 1.31 55.11 ± 0.57 55.47 ± 0.79 58.37 ± 1.14 57.27 ± 1.58 58.78 ± 0.70 57.81 ± 1.26
 MCH (pg) 19.36 ± 0.59 19.12 ± 0.51 19.06 ± 0.37 19.47 ± 0.32 20.25 ± 0.66 19.84 ± 0.90 20.71 ± 0.31 20.42 ± 0.51
 MCHC (g/dl) 34.85 ± 0.37 34.71 ± 0.51 34.60 ± 0.44 35.08 ± 0.33 34.69 ± 0.53 34.63 ± 0.71 35.24 ± 0.40 35.31 ± 0.36
 PLT (103/μl) 749.10 ± 52.24 785.90 ± 139.31 782.60 ± 147.63 629.80 ± 112.45 730.40 ± 78.00 798.60 ± 47.15 733.40 ± 75.11 732.00 ± 110.25
 LYM (103/µl) 5.55 ± 1.06 5.95 ± 1.70 6.74 ± 1.23 7.10 ± 1.89 3.87 ± 0.63 4.67 ± 0.78 4.65 ± 0.90 4.85 ± 0.69
 Lymphocytes (%) 69.35 ± 4.16 63.60 ± 5.54 64.65 ± 4.70 65.20 ± 4.28 71.45 ± 5.90 64.25 ± 6.56 72.15 ± 4.95 77.85 ± 2.78
 Neutrophils (%) 25.40 ± 3.99 31.85 ± 6.57 29.25 ± 4.27 30.45 ± 3.64 24.45 ± 5.83 30.55 ± 6.47 23.35 ± 5.01 18.95 ± 2.87
 Monocytes (%) 2.75 ± 0.98 3.05 ± 0.82 4.00 ± 0.94 2.45 ± 0.65 1.90 ± 0.60 2.50 ± 0.64 2.45 ± 0.54 2.00 ± 0.61
 Eosinophils (%) 2.45 ± 0.86 1.50 ± 0.83 2.10 ± 0.22 1.90 ± 0.72 2.20 ± 0.27 2.70 ± 0.80 2.05 ± 0.65 1.20 ± 0.57b,c
 Basophils (%) 0.05 ± 0.11 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00
Parameter Males Females
Control1 Conv. 22 11 % GMO3 33 % GMO4 Control5 Conv. 26 11 % GMO7 33 % GMO8
At 12 months
 WBC (103/μl) 9.10 ± 1.18 8.06 ± 1.32 9.41 ± 2.26 8.88 ± 1.32 6.76 ± 1.50 7.02 ± 2.29 6.15 ± 1.54 6.73 ± 1.25
 RBC (106/μl) 8.41 ± 0.26 8.37 ± 0.21 8.30 ± 0.33 8.33 ± 0.51 7.55 ± 0.39 7.69 ± 0.37 7.43 ± 0.22 7.54 ± 0.19
 HGB (g/dl) 16.59 ± 0.46 16.34 ± 0.92 16.42 ± 0.55 16.43 ± 0.33 15.93 ± 0.39 15.91 ± 0.39 15.90 ± 0.30 15.98 ± 0.45
 HCT (%) 46.99 ± 1.49 46.82 ± 1.40 45.87 ± 1.63 45.71 ± 2.33 43.62 ± 2.11 44.01 ± 1.26 43.39 ± 1.12 43.59 ± 1.07
 MCV (fl) 55.89 ± 1.32 55.99 ± 1.50 55.32 ± 1.04 55.01 ± 1.78 57.79 ± 0.94 57.33 ± 1.86 58.46 ± 0.79 57.80 ± 0.97
 MCH (pg) 19.74 ± 0.64 19.54 ± 0.95 19.82 ± 0.71 19.85 ± 1.48 21.17 ± 1.07 20.75 ± 0.86 21.43 ± 0.51 21.18 ± 0.39
 MCHC (g/dl) 35.30 ± 0.54 34.93 ± 2.14 35.84 ± 0.71 36.08 ± 2.48 36.62 ± 1.83 36.18 ± 0.54 36.66 ± 0.66 36.67 ± 0.39
 PLT (103/μl) 715.80 ± 139.47 760.30 ± 119.31 781.00 ± 124.22 746.10 ± 105.94 748.65 ± 107.91 792.40 ± 137.52 726.60 ± 133.61 773.25 ± 113.78
 LYM (103/µl) 6.03 ± 1.18 5.55 ± 1.43 6.68 ± 1.87 6.37 ± 0.82 4.43 ± 1.08 4.75 ± 1.45 4.23 ± 0.89 4.66 ± 0.81
 Lymphocytes (%) 63.60 ± 4.73 63.80 ± 7.83 63.00 ± 3.46 64.88 ± 4.66 66.43 ± 6.12 64.40 ± 5.99 64.35 ± 5.94 65.60 ± 3.17
 Neutrophils (%) 31.33 ± 4.42 30.13 ± 7.10 30.35 ± 3.44 29.20 ± 4.82 27.18 ± 6.64 31.08 ± 5.97 31.13 ± 5.08 29.30 ± 3.15
 Monocytes (%) 3.48 ± 0.74 3.25 ± 0.59 3.98 ± 0.90 3.65 ± 0.75 3.20 ± 0.65 2.68 ± 1.39 2.88 ± 1.17 2.98 ± 1.04
 Eosinophils (%) 1.60 ± 0.56 2.83 ± 1.50a,c 2.65 ± 0.49b,c 2.28 ± 1.02 3.20 ± 1.35 1.83 ± 1.09a,c 1.65 ± 0.92a,c 2.13 ± 1.03
 Basophils (%) 0.00 ± 0.00 0.00 ± 0.00 0.03 ± 0.08 0.00 ± 0.00 0.00 ± 0.00 0.03 ± 0.08 0.00 ± 0.00 0.00 ± 0.00

WBC white blood cells, RBC red blood cells, HGB haemoglobin, HCT haematocrit, MCV mean cell volume, MCH mean corpuscular haemoglobin, MCHC mean corpuscular haemoglobin concentration, PLT platelets, LYM lymphocytes

19, 10 and 20 (19 in the case of LYM) male rats fed the diet containing 33 % near-isogenic non-GM maize for 3, 6 or 12 months, respectively, were analysed

210, 10 and 20 male rats fed the diet containing 33 % conventional 2 maize for 3, 6 or 12 months, respectively, were analysed

310, 10 and 20 male rats fed the diet containing 11 % GMO maize for 3, 6 or 12 months, respectively, were analysed

49, 10 and 19 male rats fed the diet containing 33 % GMO maize for 3, 6 or 12 months, respectively, were analysed

510, 10 and 19 female rats fed the diet containing 33 % near-isogenic non-GM maize for 3, 6 or 12 months, respectively, were analysed

610, 10 and 20 female rats fed the diet containing 33 % conventional 2 maize for 3, 6 or 12 months, respectively, were analysed

710, 10 and 19 (18 in the case of PLT) female rats fed the diet containing 11 % GMO maize for 3, 6 or 12 months, respectively, were analysed

810, 10 and 20 (18 in the case of PLT) female rats fed the diet containing 33 % GMO maize for 3, 6 or 12 months, respectively, were analysed

aStatistically significant difference to control group based on one-way ANOVA, post hoc t test (p < 0.05) and post hoc Dunnett test (p < 0.05)

(a)Statistically significant difference to control group (p < 0.05) based on one-way ANOVA and post hoc t test, post hoc Dunnett test not significant

bStatistically significant difference to control group (p < 0.05) based on Wilcoxon test

cStatistically significant difference to control group based on 95 % confidence interval of the SES