Table 9.
Gross necropsy observations and histopathological findings in male Wistar Han RCC rats fed the control or 33 % GMO diet for 1 year
| Group | Animal no. | Gross necropsy observations | Histopathological findings |
|---|---|---|---|
| Control | 41 | None | No histopathological alterations |
| 42 | None | No histopathological alterations | |
| 43 | None | Focal interstitial nephritis in the left and right kidney, lymphoepithelioid granuloma in the small intestine | |
| 44 | None | No histopathological alterations | |
| 45 | None | No histopathological alterations | |
| 46 | Red-brown coloured surface on the right side of the prostate | No histopathological alterations | |
| 47 | Thickened area on the frontal bone | Bone sample not analysed | |
| 48 | None | Meibomian gland hyperplasia | |
| 49 | None | Focal mononuclear infiltration in the heart | |
| 50 | None | No histopathological alterations | |
| 51 | Brown coloured, oval-shaped mass of soft consistency in adipose tissue surrounding the left epididymis | No histopathological alterations | |
| 52 | None | Focal mononuclear infiltration in the heart, focal chronic interstitial prostatitis and lymphatic sinus ectasia | |
| 53 | None | No histopathological alterations | |
| 54 | Bilateral petechial haemorrhage (site: submandibular lymph node) | Focal mononuclear infiltration in the heart, no further histopathological alterations | |
| 55 | None | No histopathological alterations | |
| 56 | None | Tubular dilation and atrophy in the left and right kidney | |
| 57 | Grey-coloured adipose tissue surrounding the right epididymis | No histopathological alterations | |
| 58 | None | No histopathological alterations | |
| 59 | None | Cysts in the pituitary gland | |
| 60 | None | No histopathological alterations |
| Group | Animal no. | Gross necropsy observations | Histopathological findings |
|---|---|---|---|
| 33 % GMO | 1 | None | Focal mononuclear infiltration in the heart |
| 2 | Grey-coloured adipose tissue | No histopathological alteration of the adipose tissue, focal interstitial nephritis in the left and right kidney | |
| 3 | None | No histopathological alterations | |
| 4 | None | No histopathological alterations | |
| 5 | None | No histopathological alterations | |
| 6 | None | No histopathological alterations | |
| 7 | None | Lymphoepithelioid granuloma in the small intestine, focal mononuclear infiltration in the heart | |
| 8 | None | Tubular dilation and atrophy in the left and right kidney | |
| 9 | None | Cysts in the pituitary gland | |
| 10 | None | No histopathological alterations | |
| 11 | None | Cortical nodular hyperplasia in the left adrenal gland | |
| 12 | None | Cortical nodular hyperplasia in the right adrenal gland, follicular cystic hyperplasia in the thyroid gland and lymphatic sinus ectasia | |
| 13 | None | Focal cortical vacuolar degeneration in the right adrenal gland | |
| 14 | None | No histopathological alterations | |
| 15 | None | No histopathological alterations | |
| 16 | None | Focal mononuclear infiltration in the heart | |
| 17 | None | No histopathological alterations | |
| 18 | None | No histopathological alterations | |
| 19 | None | No histopathological alterations | |
| 20 | None | Tubular dilation and atrophy in the left and right kidney |