Fig. 4.

Similarities in transcriptional responses induced in cultivated hepatocytes and liver diseases. a, b Top ten upregulated genes in primary mouse (a) and human (b) hepatocytes in monolayer confluent (M _C), and in mouse liver tissue on day 1 after CCl₄ intoxication (a) or in HBV-infected human liver (b). The bars show fold changes over freshly isolated hepatocytes by gene array analysis. c Scatter plots showing all differentially expressed genes in primary mouse hepatocytes in monolayer confluent culture (day 1) and in mouse liver tissue on day 1 after CCl₄ administration (log2 scale). d Scatter plot showing all differentially expressed genes in primary human hepatocytes on monolayer confluent culture (day 1) and in HBV-infected human liver tissue. e Odds ratio analysis between differentially expressed genes in primary mouse hepatocytes (at different days on monolayer confluent culture) and mouse liver tissue on day 1 after CCl₄ administration. f Odds ratio analysis between differentially expressed genes in primary human hepatocytes (at different days on monolayer confluent culture) and mouse HBV-infected human liver tissue. Rho: correlation coefficient and its p value