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. 2016 Jun 16;594(19):5695–5710. doi: 10.1113/JP271811

Figure 6. Local pharmacological intervention in vivo .

Figure 6

A, example local field potential recordings displaying the onset of a spike and wave discharge (SWD) (S1 ctx,  somatosensory cortex; VB, ventrobasal complex of the thalamus; RTN, reticular thalamic nucleus). B, influence of local injection of saline (n = 6 rats; black line), carbenoxolone (n = 6 rats; light grey line), mefloquine (n = 6 rats; red line), ethosuximide (n = 6 rats; dark grey line) into the RTN and mefloquine into the VB (n = 4 rats; dark red line) on SWD expression in GAERS in vivo. Data are displayed as relative change to baseline (%, mean ± SEM). C, schematic overview of injection sites of either saline, mefloquine, carbenoxolone or ethosuximide, respectively, into the reticutar thalamic nucleus (RT) (red dots) or mefloquine into VB (offsite target group, green dots); this figure is adapted from Paxinos & Watson (1998).