Skip to main content
. 2016 Jun 14;594(19):5543–5554. doi: 10.1113/JP272374

Figure 1. GABAB inhibits a voltage‐gated calcium current .

Figure 1

A, whole cell currents recorded from third‐order neuron in response to voltage ramp (−70 to +50 mV) (grey trace). Application of 10 μm GABA decreased the inward calcium current and elicited a sustained outward current (green trace). Application of 100 μm picrotoxin and 50 μm TPMPA (GABAA and GABAC antagonists, respectively) alone (blue trace) and with 10 μm GABA (red trace). B, summary of similar experiments in nine cells. GABA alone suppressed the calcium current by 41 ± 8% (P < 0.01) and by 32 ± 7% (P < 0.01) in the presence of picrotoxin and TPMPA.