Figure 5. Effect of GABA_B receptor activation on outward potassium current .

A, depolarizing step to +10 mV evoked an outward potassium current (red trace) that was reduced by 10 μm baclofen (green trace). While 20 μm CGP 55845 did not reduce the outward current (blue trace), it blocked the effect of baclofen (yellow trace). B, summary of these experiments on six cells. Baclofen alone suppressed the outward current by 22 ± 6% (P < 0.01 compared to control). There was no statistically significant difference between the control outward current and the outward currents in the presence of CGP 55845 alone or in baclofen plus CGP 55845.