Figure 3. Examples of effects of auxiliary subunits on Ca_V2.2 calcium channel currents .

A, Ca_V2.2 calcium currents: effect of β subunits. Example of peak Ca_V2.2 current at 0 mV in the absence of β (blue) and presence of β1b (black). B, Ca_V2.2 calcium currents: effect of α₂δ subunits. Example of peak Ca_V2.2/β1b current at 0 mV in the absence of α₂δ (red) and presence of α₂δ‐3 (black). Scale bars apply to both A and B. Charge carrier 1 mm Ba²⁺, expression in tsA‐201 cells, as in a previous study (Leroy et al. 2005). C, effect of different α₂δ subunits on inactivation. Examples of normalized peak current for Ca_V2.2–β1b (black), Ca_V2.2–β1b–α₂δ‐2 (blue) and Ca_V2.2–β1b–α₂δ‐1 (red), over a 2.5 s timescale. Expression in Xenopus oocytes, as in a previous study (Canti et al. 2005).