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. 2016 Sep 30;10:224. doi: 10.3389/fncel.2016.00224

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Copyright © 2016 Yang, Santos, Tang, Kim and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cortical STPP. (A) Two photon image of a pyramidal neuron (Ai) and its basal dendrite with priming (blue color)/gating (green outline) glutamate uncaging spots on the individual spines in a basal dendrite (Aii). (B) The representative responses to priming plus gating (cyan trace) and gating alone (green trace) glutamate uncaging were shown as photoactivated EPSPs. When the priming stimulus preceded the gating stimulus, the facilitated response (cyan trace) was elicited in the electrical recording at the cell body (Bi). (C) NR2B selective blocker, Ifenprodil, completely blocked the neuronal facilitation (Ci). Population data of control (Bii, n = 12 cells/4 animals) and Ifenprodil (Cii, n = 5 cells/4 animals) in electrical recording of the cell body. **p < 0.01; n.s, P > 0.05.