Table 1. Identified proteins from tumoral and non tumoral prostate tissue by MS/MS data processing^a.

	Accession Numberb	Gene Nameb	Protein Nameb	IPc	MW(Da)c	Locationb	Biological Processes and Molecular Functionb	Quantification 117:115a
1.	P63104	YWHAZ	14-3-3 protein zeta/delta*	473	27745	cytoplasm	adapter protein implicated in the regulation of signaling pathways negative regulation of apoptotic process	380
2.	Q9P2A4	ABI3	ABI gene family member 3	499	39035	cytoplasm	regulation of cell migration	180
3.	P68032	ACTC1	Actin alpha cardiac muscle 1*	523	42019	cytoskeleton	cell structure and motility	227
4.	P25054	APC	Adenomatous polyposis coli protein*	793	311646	cytoplasm	signal transduction oncogenesis beta-catenin binding, protein kinase regulator activity	292
5.	O95996	APC2	Adenomatous polyposis coli protein 2	908	243949	cytoplasm and cell membrane	promotes rapid degradation of CTNNB1 and may function as a tumor suppressor May function in Wnt signaling	358
6.	Q08462	ADCY2	Adenylate cyclase*	840	123603	Citoplasm/membrane	membrane-bound and Adenylate cyclase activity	320
7.	P51825	AFF1	AF4/FMR2 family member 1*	926	131422	nucleus	oncogene transcription factor-	237
8.	P10696	ALPPL2	Alkaline phosphatase placental-like	590	57377	membrane	hydrolase with biological process unclassified	145
9.	Q99490	AGAP2	Arf-GAP with GTPase ANK repeat and PH domain-containing protein 2*	991	124674	cytoplasm and nucleus	protein transport oncogenic overexpressed in cancer cells prevents apoptosis and promotes cancer cell invasion	302
10.	Q8TF01	PNSIR	Arginine/serine-rich protein PNISR*	1002	92577	Nucleus cytoplasm	transcription system	159
11.	O14525	ASTN1	Astrotactin 1 (Fragment) *	509	144913	membrane	cell adhesion	255
12.	Q4LE39	ARID4B	AT-rich interactive domain-containing protein 4B*	504	147809	Nucleus and cytoplasm	transcriptional repressor	217
13.	O75815	BCAR3	Breast cancer anti estrogen resistance protein 3	819	92566	intracellular	guanine nucleotide responsive factor signal trasduction	721
14.	Q9UIF8	BAZ2B	Bromodomain adjacent to zinc finger domain protein 2B*	613	240459	nucleus	transcriptional regulation	164
15.	Q9NYQ7	CELSR3	Cadherin EGF LAG seven-pass G-type receptor 3	623	358185	cell membrane	cell signaling receptor	295
16.	O15484	CAPN5	Calpain-5*	757	73169	cell surface	hydrolase involved in protein metabolism and modification	116
17.	Q66K79	CPZ	Carboxypeptidase Z precursor *	822	73655	Secreted) extracellular space	metalloprotease biological process unclassified	389
18.	P35222	CTNNB1	Catenin beta-1*	553	85497	cytoplasm nucleus cell membrane	cell adhesion transcription regulation and oncogenesis	210
19.	Q96P48	ARAP1	Centaurin-delta-2	586	162192	Golgi apparatus membrane cytoplasm	GTPase activation	578
20.	Q9HC77	CENPJ	Centromere protein J*	623	153000	Cytoplasm cytoskeleton	plays an important role in cell division and centrosome function	159
21.	O14647	CHD2	Chromodomain-helicase-DNA-binding protein 2 (CHD-2) *	822	211344	nucleus	transcription regulation DNA-binding helicase	149
22.	Q8TD26	CDH6	Chromodomain-helicase-DNA-binding protein 6*	590	305412	nucleus	transcription regulator	353
23.	Q02388	COL7A1	Collagen alpha 1(VII) *	595	295220	secreted extracellular space	extracellular matrix structural constituent	207
24.	P08123	COL1A2	Collagen alpha 2(I) chain* ***	908	129314	secreted extracellular space	extracellular matrix structural constituent	319
25.	P08572	COL4A2	Collagen alpha 2(IV) chain*	885	167553	secreted extracellular space	extracellular matrix structural constituent	312
26.	P12277	CKB	Creatine kinase B-type*	535	42644	cytoplasm	central role in energy transduction in tissues	449
27.	Q9P0U4	CXXC1	CXXC-type zinc finger protein 1	861	75712	nucleus	transcription regulation	110
28.	Q9NZJ0	DTL	Denticleless protein homolog	911	79468	Nucleus and cytoplasm	cell cycle control DNA damage response and translation DNA synthesis	314
29.	P17661	DES	Desmin *	521	53536	cytoplasm	cytoskeletal protein binding muscle protein	378
30.	Q08554	DSC1	Desmocollin 1A/1B precursor	525	99987	cell membrane	cell adhesion-mediated signaling	255
31.	Q14117	DPYS	Dihydropyrimidinase *	681	56630	cytoplasm	nucleoside nucleotide and nucleic acid metabolism	630
32.	Q9Y485	DMXL1	DmX-like 1 protein *	591	337839	extracellular space	unknown	614
33.	Q9NPF5	DMAP1	DNA methyltransferase 1-associated protein 1	951	52993	Cytoplasm and nucleus	transcription repression and activation	227
34.	Q92878	RAD50	DNA repair protein RAD50*	647	153892	nucleus	hydrolase	401
35.	O60870	KIN	DNA/RNA-binding protein KIN17	907	45374	nucleus and cytoplasm	involved in DNA replication and the cellular response to DNA damage	050
36.	Q8TD84	DSCAML1	Down syndrome cell adhesion molecule-like protein 1*	843	224463	cell membrane	cell adhesion and neurogenesis	380
37.	Q96DT5	DNAH11	Dynein heavy chain 11 axonemal*	603	521043	cytoplasm	force generating protein of respiratory cilia produces force towards the minus ends of microtubules and has ATPase activity	492
38.	Q8WXX0	DNAH7	Dynein heavy chain 7 axonemal *	570	461159	cytoplasm cytoskeleton microtubule	force generating protein of respiratory cilia produces force towards the minus ends of microtubules and has ATPase activity	443
39.	Q03001	DST	Dystonin*	514	860662	cytoplasm and cytoskeleton	integrator of intermediate filaments involved in actin and microtubule cytoskeleton networks	428
40.	P14625	HSP90B1	Endoplasmin*	476	92469	endoplasmic reticulum	molecular chaperone	391
41.	Q96J88	EPSTI1	epithelial stromal interaction protein 1	990	36793	unspecified	unknown	265
42.	Q8TAM0	GPR62	G protein-coupled receptor 62*	1099	37619	Cell membrane	G-protein coupled receptor	301
43.	O94808	GFPT2	Glucosamine-fructose-6-phosphate aminotransferase [isomerizing] 2	703	76931	cytosol	aminotransferase	224
44.	Q6PCE3	PGM2L1	Glucose 16-bisphoshate syntase	681	70442	cytosol	glucose metabolism isomerase and transferase	303
45.	P30711	GSTT1	Glutathione S-transferase theta 1*	701	27335	cytoplasm	glutathione transferase activity	173
46.	Q9NU53	GINM1	Glycoprotein integral membrane protein 1	481	36840	membrane	unspecified	127
47.	Q14789	GOLGB1	Golgin subfamily B member 1*	496	376019	Golgi apparatus and membrane	unknown	050
48.	Q99062	CSF3R	Granulocyte colony stimulating factor receptor*	576	92156	cell membrane	receptor	354
49.	Q03113	GNA12	Guanine nucleotide- binding protein subunit alpha-12*	984	44279	membrane	modulators or transducers in various trans-membrane signaling systems controller of cell migration through the TOR signaling cascade	379
50.	Q96LI6	HSFY1	Heat shock transcription factor Y-linked	668	45107	nucleus cytoplasm	transcription regulation	110
51.	P69905	HBA1	Hemoglobin subunit alpha	872	15258	cytosol	oxygen transporter	497
52.	P68871	HBB	Hemoglobin subunit Beta	674	15998	cytosol	oxygen transporter	271
53.	P09105	HBQ1	Hemoglobin subunit theta-1	709	15508	cytosol	oxygen transporter	288
54.	Q8TEK3	DOT1L	Histone-lysine N-methyltransferase H3 lysine-79 specific *	939	184853	nucleus	chromatin regulator	304
55.	P17482	HOXB9	Homeobox protein Hox-B9*	901	28059	nucleus	sequence-specific transcription factor	249
56.	Q9HAS2	HIPK3	Homeodomain-interacting protein kinase 3*	716	133743	cytoplasm and nucleus	serine/threonine-protein kinase involved in transcription regulation apoptosis and steroidogenic	907
57.	P42858	HTT	Huntingtin	581	347603	cytoplasm and nucleus	may play a role in microtubule-mediated transport or vesicle function Protein binding	388
58.	Q9Y4L1	HYOU1	Hypoxia up-regulated protein 1*	516	111335	nucleus	protein metabolism and modification	229
59.	P23677	ITPKA	Inositol 145-trisphosphate 3-kinase A	759	51009	cytosol	kinase	299
60.	O15503	INSIG1	Insulin-induced protein 1*	908	29987	endoplasmic reticulum membrane	protein binding may play a role in growth and differentiation of tissues involved in metabolic control and has a regulatory role during G0/G1 transition of cell growth	098
61.	P24593	IGFBP5	Insulin-like growth factor binding protein 5 precursor*	858	30570	secreted	signal transduction and cellular protein metabolic process	306
62.	Q9BR39	JPH2	Junctophilin 2	882	74222	cell membrane	contribute to the formation of junctional membrane complexes and to the construction of skeletal muscle triad junctions	477
63.	Q01546	KRT76	Keratin type II cytoskeletal 2 oral	838	65841	cytoskeletal	cell structure and motility	293
64.	Q96L93	KIF16B	Kinesin-like protein KIF-16B*	586	152011	cytoplasm	motor protein involved in endosome transport and receptor recycling and degradation	456
65.	Q8N4N8	KIF2B	Kinesin-like protein KIF2B*	889	76254	cytoplasm	motor protein required for spindle assembly and chromosome movement	470
66.	Q32MZ4	LRRFIP1	Leucine-rich repeat flightless-interacting protein 1*	459	89253	nucleus and cytoplasm	transcriptional repressor	381
67.	Q9UNZ5	C19orf53	Leydig cell tumor 10 kDa protein homolog	1155	10577	nucleus	potential role in hyper-calcemia of malignancy	449
68.	Q9H2C1	LHX5	LIM/homeobox protein Lhx5	787	44406	nucleus	transcription regulation	412
69.	O75334	PPFIA2	Liprin-alpha2*	580	143291	cytoplasm and cell surface	protein binding	261
70.	Q9NZR2	LRP1B	Low-density lipoprotein receptor-related protein 1B*	509	515498	membrane	cell surface proteins involved in endocytosis	261
71.	Q9H239	MMP28	Matrix metalloproteinase-28	970	58939	Secreted/extracellular space	could play a role in tissues homeostasis and repair	282
72.	Q9NR99	MXRA5	Matrix-remodeling-associated protein 5*	857	312150	secreted	unknown but it is overexpressed in centenarians	332
73.	Q96JG8	MAGED4	Melanoma-associated antigen D4	634	81378	unspecified	tumor antigen	214
74.	Q8NFU7	TET1	Methylcytosine dioxygenase TET1*	853	235309	nucleus	transcription regulation activator and regulator	067
75.	P11137	MAP2	Microtubule-associated protein 2*	482	199526	cytoplasm	may stabilize the microtubules against depolymerization	272
76.	Q9NU22	MDN1	Midasin*	546	632820	nucleus	nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits	449
77.	P08235	NR3C2	Mineralocorticoid receptor (MR) *	722	107067	cytoplasm nucleus endoplasmic reticulum membrane	nuclear hormone receptor and transcription factor	262
78.	O60336	MAPKBP1	Mitogen-activated protein kinase-binding protein 1	631	163818	unknown	involved in JNK signaling pathway	500
79.	Q8WV50	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta*	520	119545	cytoplasm nucleus cytoskeleton	essential component of the mitotic checkpoint with kinase activity	237
80.	P02686	MBP	Myelin basic protein *	979	33117	peripheral membrane protein	formation and stabilization of myelin membrane	262
81.	P60660	MYL6	Myosin light polypeptide 6	446	16961	cytoskeleton	muscle protein	213
82.	P35749	MYH11	Myosin-11*	542	227339	Cytoskeleton and cytosol	muscle contraction	227
83.	Q9UKX3	MYH13	Myosin-13*	553	223605	cytoplasm	muscle contraction	693
84.	Q8WXH0	SYNE2	Nesprin-2*	526	796442	ubiquitous	involved in the maintenance of nuclear organization and structural integrity	191
85.	Q8NF91	SYNE1	Nesprin-1*	537 1011086		Nuclear cytoplasm cytoskeleton and membrane	involved in the maintenance of nuclear organization and structural integrity	222
86.	Q9ULB1	NRXN1	Neurexin-1*	561	161883	cell membrane	cell surface protein involved in cell-cell-interactions exocytosis of secretory granules and regulation of signal transmission	416
87.	Q8NFP9	NBEA	Neurobeachin*	578	327822	cytoplasm and peripheral membrane	protein localization anchoring/targeting kinase A to the membrane	359
88.	Q6KC79	NIPBL	Nipped-B-like protein *	809	316051	nucleus	involved in sister chromatid cohesion	236
89.	P04198	MYCN	N-myc proto-oncogene protein*	545	49561	nucleus	transcription factor proto-oncogene	146
90.	P23497	SP100	Nuclear autoantigen Sp-100	483	53768	nucleus and cytoplasm	transcription regulation and tumor suppressor	168
91.	Q15788	NCOA1	Nuclear receptor coactivator 1*	583	156757	nucleus	binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion Involved in the coactivation of different nuclear receptors and mediated by STAT3 STAT5A STAT5B and STAT6 transcription factors	292
92.	O00482	NR5A2	Nuclear receptor subfamily 5 group A member 2*	808	61331	nucleus	transcription regulation	237
93.	Q5VST9	OBSCN	Obscurin*	569	868484	cytoplasm	involved in miofibrillogenesis	225
94.	Q9C0B5	ZDHHC5	Palmithoyltransferase ZDHHC5	917	77545	cell membrane	acyltrasferase	202
95.	P54317	PNLIPRP2	Pancreatic lipase-related protein 2	527	51947	secreted	lipid metabolism and degradation	173
96.	Q8NG07	PNMA1	Paraneoplastic antigen Ma1	478	39761	nucleus and cytoplasmic in tumor cells	paraneoplastic antigen	408
97.	O15018	PDZD2	PDZ domain-containing protein*	818	280092	nucleus cytoplasm and endoplasmic reticulum	cell adhesion	381
98.	O95613	PCNT	Pericentrin*	540	378037	cytoplasm	protein binding	447
99.	Q5VV67	PPRC1	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1*	611	177544	nucleus	acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth	176
100.	O00541	PES1	Pescadillo homolog 1	693	68003	nucleus	ribosome biogenesis and rRNA processing	189
101.	P15259	PGAM2	Phosphoglycerate mutase	899	28766	nucleus cytosol	involved in glycolysis and gluconeogenesis	316
102.	P16284	PECAM1	Platelet endothelial cell adesion molecular	655	82536	cell membrane	protein binding	399
103.	Q9HAU0	PLEKHA5	Pleckstrin homology domain-containing family A member 5*	720	127464	cytoplasm	protein binding	294
104.	Q15149	PLEC	Plectin*	574	531791	cytoplasm	ankyrin binding and apotoptic process	258
105.	Q9NS40	KCNH7	Potassium voltage-gated channel subfamily H member 7*	757	135000	membrane	pore-forming (alpha) subunit of voltage-gated potassium channel	067
106.	Q7L014	DDX46	Probable ATP-dependent RNA helicase DDX46	933	117362	nucleus	nucleoside nucleotide and nucleic acid metabolism	178
107.	Q7Z7M1	ADGRD2	Probable G-protein coupled receptor 144*	833	104087	cell membrane	G-protein coupled receptor transducer	681
108.	P35232	PHB	Prohibitin	557	29804	Membrane and cytoplasm	DNA replication cell proliferation and differentiation proto- oncogene	347
109.	P27918	CFP	properdin	833	51276	Secreted	immunity and defense	497
110.	Q13258	PTGDR	Prostaglandin D2 receptor*	939	40271	cell membrane	receptor for prostaglandin D2	282
111.	Q9P2B2	PTGFRN	Prostaglandin F2 receptor negative regulator*	616	98556	endoplasmic reticulum membrane	protein binding	213
112.	P14921	ETS1	Protein C-ets-1*	503	50408	nucleus and cytoplasm	transcription factor	352
113.	P80511	S100A12	Protein S100-A12*	581	10575	Cytoplasm and cell membrane	signal transduction inflammatory processes and immune response	341
114.	A3KN83	SBNO1	Protein strawberry notch homolog 1*	796	154312	nucleus	regulation of transcription	412
115.	Q13882	PTK6	Protein-tyrosine kinase 6*	656	51834	cytoplasm and nucleus	involved in protein metabolism and modification implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia as well as tumor growth	479
116.	Q9Y315	DERA	Putative deoxyribose-phosphate aldolase *	908	35231	cytoplasm	lyase	189
117.	Q15311	RALBP1	RalA-binding protein 1*	568	76063	membrane	signal transduction and ATP catabolic process	213
118.	Q08999	RBL2	Retinoblastoma-like protein 2*	727	128367	nucleus	transcription factor	338
119.	Q7Z5J4	RAI1	Retinoid-acid induced protein 1*	903	203352	cytoplasm and nucleus	transcriptional regulator	229
120.	Q5T5U3	ARHGAP21	Rho GTPase-activating protein 21	785	217331	peripheral membrane protein	GTPase-activating protein	248
121.	Q9BST9	RTKN	Rhotekin	718	62667	nucleoplasm	mediates Rho signaling to activate NF-kappa-B and increases resistance to apoptosis	276
122.	Q14137	BOP1	Ribosome biogenesis protein BOP1	580	83630	nucleus	ribosome biogenesis, rRNA processing	489
123.	Q9H7B2	RPF2	Ribosome production factor 2 homolog*	1000	35583	nucleus	poly(A) RNA binding	451
124.	Q8WV20	RBMS1	RNA binding motif single stranded interacting protein 1	891	44505	nucleus	nucleoside nucleotide and nucleic acid metabolism	607
125.	P21817	RYR1	Ryanodine receptor 1*	518	565176	sarcoplasmic reticulum membrane	calcium transport	484
126.	O14641	DVL2	Segment polarity protein dishevelled homolog DVL-2*	567	78948	cell membrane and cytoplasm	Wnt signaling pathway	379
127.	Q99719	SEPT5	Septin-5	621	42777	cytoplasm	GTO and protein binding	249
128.	Q9UQ35	SRRM2	Serine/arginine repetitive matrix protein 2*	1205	299615	nucleus	pre-mRNA processing and mRNA splicing	237
129.	P15056	BRAF	Serine/Threonine protein kinase B-raf*	729	84437	nucleus and cytoplasm	proto-oncogene	394
130.	Q06190	PPP2R3A	Serine/threonine-protein phosphatase 2A regulatory subunit B’’ subunit alpha	509	130278	Colocalized with protein phosphatase type 2A complex	calcium ion and protein binding and regulator of Wnt signaling pathway	290
131.	P42345	MTOR	Serine/threonine-protein kinase mTOR*	673	288892	ubiquitous	it is a central regulator of cellular metabolism growth and survival in response to hormones growth factors nutrients energy and stress signals	257
132.	Q96Q15	SMG1	Serine/threonine-protein kinase SMG1*	603	410501	nucleus and cytoplasm	kinase involved in mRNA surveillance and genotoxic stress response pathways	379
133.	Q15464	SHB	SH2 domain-containig adapter protein B	910	55042	cytoplasm	involved in angiogenesis and apoptosis	225
134.	Q9H1V8	SLC6A17	Sodium-dependent neutral amino acid transporter SLC6A17	568	81001	cytoplasmic vesicle multi-pass membrane protein	neurotransmitter transporter	201
135.	Q96BI1	SLC22A18	Solute Carrier Family 22 member 18	662	13354	cell membrane	zinc ion binding	236
136.	O94956	SLCO2B1	Solute carrier organic anion transporter family member 2B1*	870	76711	cell membrane	ion transport	171
137.	P11277	SPTB	Spectrin beta chain erythrocytic*	515	246468	cytoplasm	cell structure and motility	127
138.	Q9BPZ7	MAPKAP1	Stress-activated map kinase interacting protein 1	724	59123	cell membrane and nucleus	stress response and phosphatidic acid binding	463
139.	Q15431	SYCP1	Synaptonemal complex protein 1*	578	114192	Nucleus and chromosome	cell cycle and meiosis	342
140.	Q9BQ70	TCF25	Transcription factor 25*	595	76667	nucleus	transcriptional repressor	406
141.	Q01664	TFAP4	Transcription factor AP-4	563	38726	nucleus	transcription regulator	348
142.	Q8NHW3	MAFA	Transcription factor mammalian MafA*	749	36982	nucleus	transcriptional factor	941
143.	Q8NEM7	SUPT20H	Transcription factor SPT20 homolog	877	85789	nucleus	required for MAP kinase p38 (MAPK11 MAPK12 MAPK13 and/or MAPK14)	421
144.	P29084	GTF2E2	Transcription initiation factor IIE subunit beta	966	33044	nucleus	basal transcription factor	227
145.	O75410	TACC1	Transforming acidic coiled-coil-containing protein 1*	481	87794	cytoplasm and nucleus	cell cycle and division	555
146.	Q01995	TAGLN	Transgelin*	887	22611	cytoplasm	muscle protein	099
147.	Q9UJA5	TRTM6	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6	718	55799	nucleus	tRNA processing	205
148.	Q9NYL9	TMOD3	Tropomodulin-3	508	39595	cytoplasm	blocks the elongation and de-polymerization of the actin filaments	122
149.	P06753	TPM3	Tropomyosin alpha-3-chain	468	32950	cytoplasm and cytoskeleton	muscle protein	294
150.	P07951	TPM2	Tropomyosin beta chain	466	32851	cytoplasm and cytoskeleton	muscle protein	067
151.	P49815	TSC2	Tuberin*	698	200608	cytoplasm	tumor suppressor and intracellular protein traffic	401
152.	P07437	TUBB	Tubulin beta chain*	478	49671	cytoplasm and cytoskeleton	protein binding and structural constituent of cytoskeleton	435
153.	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1*	651	54967	membrane	involved in intracellular signaling during synaptogenesis and in synaptic function	276
154.	Q9NPG3	UBN1	Ubinuclein-1*	937	121520	nucleus, cell junction	novel regulator of senescence	262
155.	Q14139	UBE4A	Ubiquitin conjugation factor E4 A*	511	123522	cytoplasm	protein metabolism and modification	261
156.	Q9Y6A4	CFAP20	Cilia- and flagella-associated protein 20*	978	22774	nucleus	transcription factor	093
157.	Q15849	SLC14A2	Urea transporter 2*	651	101209	cell membrane	transport protein	127
158.	Q8N6Y0	USHBP1	Usher syndrome type-1C protein-binding protein 1	558	76068	cytoplasm nucleus plasma membrane	signal transduction	169
159.	P62955	CACNG7	Voltage-dependent calcium channel gamma 7 subunit	665	31003	membrane	calcium transport	346
160.	P21281	ATP6V1B2	V-type proton ATPase subunit B brain isoform	557	56501	peripheral membrane protein	cation transport	148
161.	Q9UJW8	ZNF180	Zinc finger protein 180 (HHZ168)*	804	79111	nucleus	involved in transcriptional regulation	193
162.	Q7Z3V5	ZNF571	Zinc finger protein 571*	871	70792	nucleus	involved in transcriptional regulation	354
163.	Q9H582	ZNF644	Zinc finger protein 644	843	149565	nucleus	involved in transcriptional regulation	369
164.	Q15776	ZKSCANS	Zinc finger protein with KRAB and SCAN domains 8	704	65816	nucleus	transcription factor	312

^aThe identification and quantitation of proteins were performed using the Protein Pilot Paragon Method The MS/MS data were processed using a mass tolerance of 10 ppm and 02 Da for the precursor and fragment ions respectively

^bAccording to “UniProtKB” (http://wwwuniprotorg/)

^cAccording to “Compute pI/MW” (http://webexpasyorg/compute_pi/)

^*Proteins involved in epithelial neoplasia (p-value=362E-05).