Table 2.
PARP-2-deficient mouse models
| Genotype | Developmental defects | Fertility defects | Spontaneous tumorigenesis | Ref. |
|---|---|---|---|---|
| Parp-2-/- | Impaired thymopoiesis, adipogenesis, spermatogenesis, fetal liver erythropoiesis | Hypofertility, testicular hypoplasia, oligospermia | None | [13,23-25,51] |
| Parp-2-/-Parp-1-/- | Early embryonic lethality | NA | NA | [27] |
| Parp-2-/-Atm-/- | Early embryonic lethality | NA | NA | [7] |
| Parp-2-/-p53-/- | Partial embryonic lethality | None | Early onset of T cell lymphoma | [51] |
| Parp-2-/-p21-/- | Newborn lethality due to impaired fetal liver erythropoiesis | NA | NA | [25] |
| Parp-2-/-Xrcc5-/- | Partial newborn lethality and growth retardation | NA | NA | [52] |
| Parp-2-/-Prkdc-/- | Shortened lifespan and accumulation of telomere fusions similar to Parp-2+/-Prkdc-/- | Unknown | 50% thymic lymphoma similar to Parp-2+/-Prkdc-/- | [52] |
| Parp-2-/-H2afx-/- | Early embryonic lethality | NA | NA | [52] |
NA, not applicable.