Overexpression of Skp2 promoted cell proliferation and inhibited apoptosis in PC cells. A: The effect of Skp2 overexpression in combination with curcumin treatment on PC cell growth was detected by CTG assay. Control: control cDNA (pcDNA 3.1); cDNA: Skp2 cDNA; Both: Skp2 cDNA+Curcumin. B: Cell apoptosis was accessed by Flow cytometry. *P < 0.05, **P < 0.01, compared with control; #P < 0.05 compared with curcumin treatment or Skp2 cDNA transfection. C. Left panel, the PC cells invasion was detected after Skp2 cDNA transfection and curcumin treatment. Right panel, Quantitative results are illustrated for left panel. *P < 0.05, **P < 0.01, compared with control; #P < 0.05 compared with curcumin treatment or Skp2 cDNA transfection.