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. 2016 Sep 30;6:34220. doi: 10.1038/srep34220

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A,B) Multi-dimensional scaling plots (MDSplots) based on the 2-D projection of the Euclidean distances calculated between samples using the 5000 most variable CpG positions. (A) Autosomal methylation data and (B) X-chromosomal methylation data, both illustrating clear segregation according to the TS karyoype. Note that for X-chromosomal methylation data we only compare the one X-chromosome in TS with one of males (B). (C,D) MDSplots based on the biological coefficient of variation (BCV) derived from the expression data. (C) Autosomal expression data with no clear clustering. (D) X-chromosomal expression data showing clustering according to karyotype. Green = Turner syndrome; Purple = Male controls; Orange = Female Controls.