Table 1. Characteristics of SNPs in ion transport genes in the subcohort members of the Netherlands cohort study, 1986–2006.
| SNPs in salt transporter genes | Chr. location | Ref. alleles | Minor allele | MAF | Genotypes |
HWEb | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 11a |
12a |
22a |
|||||||||
| n | % | n | % | n | % | ||||||
| ADD1_rs4961 | 4p16.3 | G/T | T | 0.212 | 2,232 | 62.33 | 1,182 | 33.01 | 167 | 4.66 | 0.52 |
| ATP1A1_rs850602 | 1p21 | C/G | G | 0.236 | 2,089 | 58.35 | 1,290 | 36.03 | 201 | 5.61 | 0.93 |
| ATP1B1_rs2901029 | 1q24 | A/G | G | 0.432 | 1,176 | 32.83 | 1,716 | 47.91 | 690 | 19.26 | 0.15 |
| GNB3_rs1129649 | 12p13 | C/T | C | 0.351 | 1,536 | 42.87 | 1,582 | 44.15 | 465 | 12.98 | 0.07 |
| GNB3_rs4963516 | 12p13 | A/C | C | 0.148 | 2,607 | 72.76 | 894 | 24.95 | 82 | 2.29 | 0.60 |
| RGS5_rs2815287 | 1q23.1 | A/C | C | 0.377 | 1,371 | 38.27 | 1,4718 | 47.96 | 493 | 13.76 | 0.23 |
| RGS5_rs2999967 | 1q23.1 | C/T | C | 0.461 | 1,057 | 29.51 | 1,750 | 48.86 | 775 | 21.64 | 0.31 |
| SCNN1B_rs11645151 | 16p12.2-p12.1 | C/T | C | 0.251 | 1,993 | 55.70 | 1,371 | 38.32 | 214 | 5.98 | 0.31 |
| SCNN1B_rs239345 | 16p12.2-p12.1 | A/T | A | 0.252 | 1,994 | 55.67 | 1,368 | 38.19 | 220 | 6.14 | 0.51 |
| SCNN1G_rs4299163 | 16p12 | C/G | C | 0.207 | 2,193 | 64.01 | 1,050 | 30.65 | 183 | 5.34 | <0.001 |
| SLC9A3_rs4957061 | 5p15.3 | C/T | T | 0.470 | 942 | 28.13 | 1,664 | 49.69 | 743 | 22.19 | 0.89 |
| STK39_rs6749447 | 2q24.3 | G/T | G | 0.268 | 1,928 | 53.88 | 1,379 | 38.54 | 271 | 7.57 | 0.27 |
| WNK1_rs10849563 | 12p13.3 | A/G | G | 0.306 | 1,748 | 49.45 | 1,413 | 39.97 | 374 | 10.58 | <0.001 |
aGenotypes 11, 12 and 22 refer to the homozygote common, heterozygote and homozygote rare genotype, respectively.
bP-value for Hardy-Weinberg equilibrium.