Table 4. Summary of P values for interaction between dietary intakes, hypertension and use of diuretic medication and SNPs in ion transport genes for renal cell cancer risk in the Netherlands Cohort Study, 1986–2006.

SNPs in ion transport genesc	P for interactiona,b
	Sodium intake (g/d)d	Potassium intake (g/d)d	Fluid intake (L/d)	Use of diuretic medication	Doctors’ diagnosis of hypertension
ADD1_rs4961	0.101	0.279	0.346	0.875	0.990
ATP1A1_rs850602	0.336	0.684	0.847	0.535	0.091
ATP1B1_rs2901029	0.854	0.363	0.710	0.605	0.187
GNB3_rs1129649	0.355	0.942	0.706	0.276	0.026e
GNB3_rs4963516	0.518	0.529	0.895	0.633	0.552
RGS5_rs2815287	0.353	0.061	0.701	0.863	0.692
RGS5_rs2999967	0.742	0.723	0.356	0.285	0.356
SCNN1B_rs11645151	0.481	0.275	0.797	0.326	0.498
SCNN1B_rs239345	0.507	0.268	0.647	0.699	0.376
SCNN1G_rs4299163	0.233	0.069	0.860	0.059	0.109
SLC9A3_rs4957061	0.827	0.028e	0.031e	0.013e	0.399
STK39_rs6749447	0.279	0.751	0.498	0.147	0.338
WNK1_rs10849563	0.496	0.727	0.881	0.290	0.068

^aUsing Wald χ² test for interaction.

^bInteraction adjusted for age at baseline (years), sex (male/female), total energy intake (kcal per day), smoking status (non-current/current), smoking intensity (cigarettes per day), smoking duration (years), BMI (Kg per m²), alcohol intake (grams of ethanol per day), hypertension (yes/no) and use of diuretic medication (yes/no).

^cSNPs are analyzed in a dominant model.

^dIntakes are energy-adjusted by using the residual mean method.

^eFDR-adjusted p-value: 0.504.