Fig. 6.

Case 6: follow-up contrast-enhanced CT 3 months after initiation of ado-trastuzumab emtansine showed features of pseudocirrhosis. Contrast-enhanced axial (a–c) CT images show interval atrophy of both the right and left hepatic lobes, with diffuse surface nodularity (red arrows in a, b). Ill-defined, linear, ‘band like’ masses that extend to the periphery of the liver (yellow arrows in a–c) correspond to bands of fibrosis. Changes of portal hypertension are present with splenomegaly, paraesophageal varices (blue circle in a) and new ascites (green star in b).