Figure 1. Genome-wide DNA methylation profiling in subchondral bone of knee OA.
(A) Heat map of identified significant differentially methylated probes (DMPs) in iLT/oLT and iMT/oLT comparison groups. The methylation scale was shown on the top (0 = no methylation, 1 = 100% methylation). Horizontal axis: samples from the oLT, iLT and iMT region. Vertical axis: the dendrogram showing the clusters of DMPs. (B) β value plot of selected top DMPs in the iLT/oLT, iMT/oLT and iMT/iLT groups. Cg05209996 did not map to a gene. Cg03993743, cg19346371 and cg10703828 mapped SIM2, TBX3 and TBX15, respectively.