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. 2016 Sep 30;6:34501. doi: 10.1038/srep34501

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The lower images show the hearts of the E11.5 to E16.5 control and mutant embryos shown in the upper images. At E14.5, E15.5 and E16.5, all of the mutant embryos exhibiting hemorrhages, a pale body surface or no abnormal appearance displayed abnormal heart morphology. The arrows indicate the interventricular sulcus.