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. 2016 Sep 30;6:34501. doi: 10.1038/srep34501

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Copyright © 2016, The Author(s)

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(A,B) Mutant embryos (RCLG/EIIa-Cre) exhibit aberrantly elevated levels of primitive erythrocytes at E14.5 and E15.5. (A) H&E staining of paraffin sections of representative E12.5 to E15.5 control and mutant embryos were stained with H&E. These representative sections focused on showing the nucleated red blood cells (NRBCs) in mutant and control embryos between E12.5 and E15.5. (B) The percentage of nucleated red blood cells (NRBCs) in E12.5 to E15.5 embryos. RBCs: red blood cells. (C) The mechanisms underlying embryonic lethality due to constitutive Cripto-1 expression in transgenic mice.