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. 2016 Sep 30;6:34621. doi: 10.1038/srep34621

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Copyright © 2016, The Author(s)

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(A) Effects of 4 doses of Ang-(1–7) (0.1, 1, 10, 100 nmol/L) treatment on VSMCs proliferation; (B) effects of 4 doses of Ang II (0.1, 1, 10, 100 nmol/L) on VSMCs proliferation; (C) effects of control, Ang-(1–7) (100 nmol/L), Ang II (100 nmol/L), Ang-(1–7)+Ang II, A-779 (100 nmol/L), A-779+Ang-(1–7)+Ang II on VSMCs proliferation; (D) effects of A-779 (100 nmol/L) and losartan (100 nmol/L) on VSMCs proliferation or on Ang II (100 nmol/L) induced VSMCs proliferation response; (E) effects of control, Ang-(1–7) (100 nmol/L), Ang II (100 nmol/L), Ang-(1–7)+Ang II, A-779 (100 nmol/L), A-779+Ang-(1–7)+Ang II on PCNA expression in VSMCs. Values are mean ± SE. *P < 0.05 vs. control; ^†P < 0.05 vs. Ang II. (A–D), n = 6 for each group; (E) n = 3 for each group.