Figure 2. Fluoxetine failed to rescue the increase of depression-like behaviors in Wip1 KO mice.

(A) Wip1 KO mice consumed less sucrose in the sucrose preference test (SPT) than the control mice did, but fluoxetine treatment for 2 weeks failed to prevent the decrease of sucrose consumption in Wip1 KO mice. (B) Neither Wip1 KO nor fluoxetine treatment affect the immobility time in the forced swimming test (FST). However, Wip1 KO significantly decreased the latency to be immobile in FST, though this phenotype was not successfully blocked by fluoxetine treatment. (C) Fluoxetine treatment failed to prevent Wip1 KO-induced increase of the immobility time in the tail suspension test (TST). n = 11 for each of the two KO groups; n = 7 mice for each of the two WT groups. *P < 0.05; **P < 0.01.