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. 2016 Sep 30;6:34558. doi: 10.1038/srep34558

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Copyright © 2016, The Author(s)

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(A) Illustration of SABG-staining positive cells located in hippocampal CA1 and DG subareas. (B) Fluoxetine treatment for 2 weeks did not prevent the increase of cellular senescence in Wip1 KO mice (n = 5 mice for each group). (C) Illustration of hippocampal γ-H2AX positive cells after fluoxetine or vehicle treatment for 2 weeks in both groups. (D) Fluoxetine treatment was unable to prevent the increase of γ-H2AX positive cells in hippocampus of Wip1 KO mice (n = 6 mice for each group). (E) The expression of γ-H2AX and the total H2AX were examined using Western blotting assay. (F) Fluoxetine treatment was unable to prevent the increase of hippocampal γ-H2AX activity in Wip1 KO mice (n = 6 samples for each group). The expression of γ-H2AX was normalized to that of the total H2AX. **P < 0.01.