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. 2016 Sep 30;6:34558. doi: 10.1038/srep34558

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Copyright © 2016, The Author(s)

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(A) CUMS-induced decrease of sucrose consumption in SPT was significantly prevented following fluoxetine treatment for 2 weeks. (B) Fluoxetine treatment effectively prevented CUMS-induced increase of the immobility time, and the reduction of the latency to immobility in FST. (C) Fluoxetine treatment effectively prevented CUMS-induced increase of the immobility time in TST. n = 8 mice for each group. (D) Illustration of SABG-staining positive cells within CA1 and DG subareas of CUMS-exposed mice and their controls treated with fluoxetine or vehicle. (E) Fluoxetine treatment effectively prevented the increase of cellular senescence within CA1 and DG subareas of CUMS-exposed mice (n = 6 mice for each group). *P < 0.05; **P < 0.01.