Table 1. Univariate and multivariate Cox regression analysis predicts disease recurrence and progression in patients with UC.

Predictors	Recurrence				Progression
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR	P	HR	P	HR	P	HR	P
Age (≧65 yrs vs ≦65 yrs)	1.79	0.021	1.71	0.034**	2.35	0.046	2.35	0.096
Gender: males vs female	1.003	0.99	1.089	0.722	1.048	0.899	1.036	0.481
Tumor size
1–3 cm vs <1 cm	1.194	0.535	1.31	0.371	5.59	0.02	5.15	0.031
≧3 cm vs <1 cm	1.022	0.933	1.11	0.794	4.67	0.05	1.93	0.46
Grade: High vs Low	1.08	0.754	1.03	0.909	2.63	0.027	2.53	0.034
Stage
T2 vs Tis/Ta/T1	1.52	0.157	1.346	0.3	1.08	0.867	1.07	0.893
T3/T4 vs T2	1.72	0.75	1.249	0.41	1.18	0.686	1.17	0.385
Numbers of tumors: multiple vs single	1.10	0.678	1.10	0.644	5.58	0.02	1.568	0.367
Lymph node status: metastatsis	2.058	0.16	1.923	0.206	1.23	0.776	1.079	0.47
Lymphovascular invasion: positive	1.196	0.609	1.017	0.963	1.71	0.46	1.58	0.46
Chemotherapy*: Yes, no	1.16	0.501	1.01	0.965	1.54	0.227	1.42	0.338
Surgical margin: positive vs negative	1.37	0.493	1.14	0.774	7.58	<0.001	4.13	0.031
m/z 5947: positive	2.36	0.001	2.29	0.001**	2.77	0.025	3.11	0.039**
m/z 5593: positive	1.54	0.647	1.27	0.289	1.156	0.683	1.222	0.649

HR: Hazard ratio; pT, pathological tumor; *Chemotherapy includes intravesical treatment and neoadjuvant chemotherapy **p < 0.05.