Table 2. Correlations of IHC staining score of alpha-1 antitrypsin and H2B1K with clinical parameters.

IHC staining	Normal versus UC			p value
	Normal (26)	UC (122)
Alpha-1-antirtypsin	55.48	78.55		0.002*
H2B1K	54.13	78.84		0.007*
Age
	<65 (19)	≥65 (103)
Alpha-1-antirtypsin	54.89	62.72		0.299
H2B1K	57.47	62.24		0.587
Grade
	Low (46)	High (76)
Alpha-1-antirtypsin	51.73	67.41		0.005*
H2B1K	70.01	56.35		0.037*
Tumor size
	<1 cm (61)	1–3 cm (43)	≥3 cm (18)
Alpha-1-antirtypsin	53.01	60.78	92	<0.001*
H2B1K	62.28	62.29	56.03	0.773
Number of tumors
	Single (72)	Multiple (49)
Alpha-1-antirtypsin	64.41	55.99		0.129
H2B1K	61.17	60.74		0.947
T
	Ta + Tis	T1 + T2	T3 + T4
Alpha-1-antirtypsin	49.88	62.94	61.48	0.512
H2B1K	94.25	56.13	63.43	0.013*
N
	N0 (117)	N1 (2)	N2 (2)
Alpha-1-antirtypsin	59.97	70.25	111.75	0.046
H2B1K	60.75	70.5	66.0	0.907
M
	M0 (117)	M1 (5)
Alpha-1-antirtypsin	60.43	86.6		0.057
H2B1K	62.9	28.7		0.033*
Stage
	0 (7)	I + II (64)	III (38)	IV (13)
Alpha-1-antirtypsin	51.29	61.13	56.07	84.69	0.021*
H2B1K	95.64	58.06	62.01	58.54	0.062