Table I.

Successful and failed treatments of Rosai-Dorfman disease with thalidomide in the literature

Patient	Age (y)/sex	Presentation	Site	Additional history	Duration before diagnosis	Treatment prethalidomide	Dosage/duration of thalidomide treatment	Response to thalidomide/follow-up
15	43/M	Papules and crusting	Face, chest, and upper extremities	Negative	12 mo	-Methylprednisone, 36 mg/d for 3 mo -20 Gy of fractionated local radiation -Betamethasone dipropionate/betamethasone disodium phosphate injection	50 mg/d for 2 wk, 100 mg/d for 8 mo	Near resolution of nodules in face and limbs with lightening of erythematous papules 2 y: no recurrence of lesions
26	45/F	Erythematous papules and plaques	Bilateral cheeks, periorbital, neck, inner thighs	Polyclonal hypergammaglobulinemia, elevated ESR	5 mo	-Hydroxychloroquine, 200 mg BID for 7 d -Dapsone, 100 mg/d for 21 d -Prednisolone, 30 mg/d for 14 d	300 mg/d	Gradual regression 5 mo: all lesions resolved except scattered axillary lesions
310	41/F	Erythematous papules and plaques	Face, neck, periorbital, limbs, upper trunk	Uveitis, IgG hyperglobulinemia, mild anemia, elevated ESR	2 mo	N/A	300 mg/d, tapering to 150 mg/d	22 mo: partial response
410	60/M	Erythematous plaques/nodules with satellite papules	Back	Negative	4-5 mo	N/A	300 mg/d	4 mo: clearing of old lesions
511	72/F	Erythematous papules	Right breast	Negative	8 mo	-Clobetasol propionate for 2 mo -Acitretin, 25 mg/d for 3 mo	50 mg/d for 1 mo, 100 mg/d for 5 mo	Minimal response Response to methotrexate 0.25 mg/kg within 1 mo, sustained partial response with methotrexate at 6 mo
612	41/F	Erythematous papules, plaques, and nodules	Right cheek from inner canthus to nasal ala	Negative	10 mo	-Oral antibiotics -Oral glucocorticoids	50 mg/d for 3 mo	Significant improvement No follow up information
713	70/M	Erythematous nodules	Right chest	Negative	1 y	-Intralesional betamethasone	300 mg/d for 8 mo	No improvement on thalidomide Surgical excision of nodes; no recurrence after 1 y