T1 images from three participants with TBI with their FIRST output overlaid in colour (green = thalamus, blue = hippocampus, red = amygdala). Participant A: Male, 30 years, Acute left subdural haematoma, multiple left and parietal petechial haemorrhages and oedema, left frontal haematoma. Participant B: Male, 29, Bilateral subdural haematomas and fronto-temporal contusion. Participant C: Female, 59 years, Right temporal haematoma, right frontal contusion and fractured occipital bone.” (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)