Table 3.
Age, sex and fasting-adjusted associations between the plasma metabolites and ADHD-like behavioural scores
Putative annotation | Total ADHD | Inattention | Impulsivity | ||||||
---|---|---|---|---|---|---|---|---|---|
Original | Adjusted | Original | Adjusted | Original | Adjusted | ||||
p | rs | p | p | rs | p | p | rs | p | |
Putative carnitine | 0.017 | 0.560 | 0.013 | 0.036 | 0.527 | 0.02 | 0.016 | 0.526 | 0.021 |
1-methylnicotinamide | 0.001 | 0.642 | 0.003 | 6.86E-04 | 0.671 | 0.002 | 0.005 | 0.576 | 0.010 |
Kynurenic acid (KYNA) | 0.015 | 0.519 | 0.023 | 0.017 | 0.486 | 0.035 | 0.018 | 0.543 | 0.016 |
Phelynalanine | ns | ns | ns | ns | ns | ns | 0.049 | 0.435 | 0.063 |
Indoleacetic acid | ns | ns | ns | 0.030 | −0.448 | 0.062 | ns | ns | ns |
3-Indolepropionic acid (IPA) | 0.006 | −0.578 | 0.010 | 0.002 | −0.655 | 0.002 | 0.035 | −0.442 | 0.058 |
Unknown metabolite m/z 221.150 | 0.039 | 0.426 | 0.069 | 0.013 | 0.475 | 0.040 | ns | ns | ns |
sn-1 LysoPC(14:0) | ns | ns | ns | 0.049 | −0.387 | 0.102 | ns | ns | ns |
sn-1 LysoPC(18:3) | 2.93E-05 | −0.782 | 7.54E-05 | 8.26E-05 | −0.765 | 1.34E-04 | 3.32E-05 | −0.785 | 6.86E-05 |
sn-1 LysoPE(20:5) | 0.009 | −0.569 | 0.011 | 0.002 | −0.615 | 0.005 | 0.037 | −0.499 | 0.030 |
sn-1 LysoPC(15:0) | 0.002 | −0.640 | 0.003 | 0.003 | −0.598 | 0.007 | 8.46E-04 | −0.701 | 8.0E-04 |
sn-1 LysoPE(18:2) | 0.002 | −0.670 | 0.002 | 0.003 | −0.703 | 8.0E-04 | 0.008 | −0.645 | 0.003 |
sn-1 LysoPE(18:1) | ns | ns | ns | 0.011 | −0.493 | 0.032 | ns | ns | ns |
sn-1 LysoPC(20:3) | 0.016 | −0.550 | 0.015 | 0.021 | −0.555 | 0.014 | 0.014 | −0.561 | 0.013 |
sn-1 LysoPC(17:0) | 0.035 | −0.463 | 0.046 | 0.041 | −0.447 | 0.055 | 0.038 | −0.499 | 0.030 |
sn-1 LysoPE(18:0) | 0.006 | −0.610 | 0.006 | 0.005 | −0.622 | 0.004 | 0.01 | −0.600 | 0.007 |
Arachidonic acid (C20:4) | 0.016 | 0.502 | 0.029 | 0.005 | 0.555 | 0.014 | ns | ns | ns |
Unknown metabolite, putative GlcCer(d18:1/12:0) or GlcCer(d14:1/16:0) | 0.017 | 0.514 | 0.024 | 0.012 | 0.547 | 0.015 | 0.037 | 0.473 | 0.041 |
C18:1 | 0.016 | 0.508 | 0.026 | 0.011 | 0.524 | 0.021 | 0.025 | 0.505 | 0.028 |
Unknown metabolite, putative Cer(d18:1/24:1) | 0.016 | 0.506 | 0.027 | 0.010 | 0.529 | 0.020 | 0.031 | 0.488 | 0.034 |
Bilirubin | 0.015 | 0.511 | 0.025 | 0.005 | 0.544 | 0.016 | 0.035 | 0.515 | 0.024 |
PC(20:5/18:3) | 0.009 | −0.601 | 0.008 | 0.003 | −0.615 | 0.007 | ns | ns | ns |
Unknown PC m/z 796.516 | ns | ns | ns | 0.029 | −0.404 | 0.087 | ns | ns | ns |
PC(20:4/14:0) | 0.007 | −0.559 | 0.013 | 0.007 | −0.538 | 0.017 | 0.022 | −0.531 | 0.019 |
PC(18:3/18:2) | 1.19E-05 | −0.804 | 9.91E-05 | 2.53E-05 | −0.785 | 1.89E-04 | 2.52E-04 | −0.767 | 3.24E-04 |
PC(18:2/16:1) | 0.013 | −0.529 | 0.020 | 0.018 | −0.537 | 0.018 | 0.022 | −0.476 | 0.039 |
PC(15:0/18:2) | 0.005 | −0.604 | 0.006 | 0.006 | −0.578 | 0.010 | 0.012 | −0.590 | 0.008 |
Spearman correlation coefficients (corrected rs) from partial correlation analysis including age, sex and fasting status as covariates together with statistical significance (adjusted p). Original p values are also shown (original p)