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. 2016 Sep 29;9:102. doi: 10.1186/s13045-016-0326-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic diagram of the study. a Schematic diagram of deriving CD34⁺ cells from human iPSCs by utilizing a synthetic 3D niche system in our study. b The protocol for stepwise specification of human iPSCs into hematopoietic cells