Table 2.
Correlation of plasma MCP-1 with immune and clinical biomarkers
| Marker | Diabetic | Non-diabetic | ||||||
|---|---|---|---|---|---|---|---|---|
| Asthmatic | Non-asthmatic | Asthmatic | Non-asthmatic | |||||
| r | P | r | P | r | P | r | P | |
| IFN-α2 | 0.62 | 0.05* | −0.31 | 0.28 | 0.38 | 0.07 | −0.31 | 0.12 |
| IL-1α | −0.37 | 0.46 | 0.28 | 0.64 | 0.18 | 0.53 | −0.57 | 0.01* |
| IL-1β | 0.16 | 0.79 | 0.53 | 0.63 | 0.77 | 0.002** | −0.62 | 0.01* |
| IL-1RA | 0.65 | 0.03* | −0.40 | 0.17 | 0.42 | 0.05* | −0.25 | 0.21 |
| IL-2 | −0.40 | 0.43 | −0.76 | 0.07 | 0.51 | 0.07 | −0.49 | 0.03* |
| IL-3 | 0.16 | 0.74 | −0.70 | 0.05* | −0.17 | 0.57 | −0.78 | 0.0002*** |
| IL-6 | 0.24 | 0.56 | 0.64 | 0.04* | 0.39 | 0.11 | −0.11 | 0.62 |
| IL-9 | 0.16 | 0.79 | −0.85 | 0.02* | −0.30 | 0.26 | −0.76 | 0.0004*** |
| IL-10 | 0.70 | 0.02* | −0.34 | 0.26 | 0.27 | 0.26 | 0.18 | 0.38 |
| IL-12p70 | 0.22 | 0.52 | −0.48 | 0.09 | 0.27 | 0.23 | −0.26 | 0.20 |
| MDC/CCL-22 | −0.01 | 0.97 | 0.01 | 0.96 | 0.44 | 0.03* | 0.37 | 0.07 |
| MIP-1α/CCL-3 | 0.07 | 0.87 | −0.62 | 0.02* | −0.01 | 0.96 | 0.20 | 0.35 |
| MIP-1β/CCL-4 | 0.38 | 0.27 | −0.64 | 0.02* | 0.15 | 0.48 | −0.19 | 0.40 |
| RANTES/CCL-5 | −0.02 | 0.97 | 0.05 | 0.90 | 0.57 | 0.06 | 0.01 | 0.97 |
| GRO-α/CXCL-1 | 0.47 | 0.16 | 0.54 | 0.05* | 0.22 | 0.30 | 0.10 | 0.62 |
| IP-10/CXCL-10 | 0.57 | 0.08 | 0.16 | 0.61 | 0.72 | <0.0001*** | 0.18 | 0.37 |
| Fractalkine | 0.70 | 0.02* | −0.42 | 0.14 | 0.28 | 0.18 | −0.30 | 0.14 |
| G-CSF | 0.38 | 0.27 | −0.49 | 0.08 | 0.34 | 0.11 | −0.07 | 0.71 |
| GM-CSF | 0.49 | 0.15 | −0.37 | 0.20 | 0.54 | 0.007** | −0.27 | 0.17 |
| FGF-2 | 0.40 | 0.24 | −0.12 | 0.68 | 0.53 | 0.01* | 0.10 | 0.62 |
| PDGF-AA | −0.39 | 0.51 | 0.11 | 0.74 | 0.68 | 0.04* | −0.39 | 0.20 |
| PDGF-BB | 0.11 | 0.89 | −0.01 | 0.97 | 0.91 | 0.03* | −0.48 | 0.12 |
| VEGF | 0.71 | 0.02* | −0.005 | 0.99 | 0.26 | 0.21 | 0.09 | 0.65 |
| FLT-3 L | −0.30 | 0.55 | −0.61 | 0.07 | 0.01 | 0.99 | −0.16 | 0.50 |
| IgE | 0.61 | 0.06 | −0.39 | 0.38 | 0.25 | 0.26 | 0.19 | 0.57 |
| BMI (kg/m2) | −0.19 | 0.59 | −0.54 | 0.05* | 0.18 | 0.39 | 0.40 | 0.04* |
| FPG (mmol/L) | −0.11 | 0.74 | 0.20 | 0.51 | 0.40 | 0.06 | 0.46 | 0.02* |
| HbA1c (%) | 0.03 | 0.93 | −0.24 | 0.42 | 0.47 | 0.02* | 0.40 | 0.05* |
| TG (mmol/L) | 0.25 | 0.47 | −0.12 | 0.68 | 0.21 | 0.31 | 0.48 | 0.01* |
IFN Interferon, IL interleukin, CCL CC chemokine ligand, CXCL CXC chemokine ligand, MDC macrophage derived chemokine, MIP macrophage inflammatory protein, RANTES regulated on activation, normal T-cell expressed and secreted, GRO growth regulated oncogene, IP IFN-γ-inducible protein, G-CSF granulocyte colony-stimulating factor, GM-CSF granulocyte-macrophage colony-stimulating factor, FGF fibroblast growth factor, PDGF platelet derived growth factor, VEGF vascular endothelial growth factor, FLT-3 L FMS-like tyrosine kinase 3 ligand, IgE immunoglobulin E
All statistical values are indicated in boldface
*significant, **highly significant, ***extremely significant