Table 2.
GRADE evidence table for the comparison betalactam antibiotics vs. doxycycline for children with Lyme neuroborreliosis
| Quality assessment | № of patients | Effect | Quality | ||||||
|---|---|---|---|---|---|---|---|---|---|
| № of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Betalactam antibiotics | Doxycycline | Relative (95 % CI) | |
| Neurological symptoms at last reported time point | |||||||||
| 3 | observational studies | very seriousa | not serious | seriousb | seriousc | 15/195 (7.7 %) | 3/25 (12.0 %) | not pooled | ⨁◯◯◯ VERY LOW |
abaseline confounding, selected patients, lack of blinding, interventions insufficiently described
bheterogeneous interventions, interventions not clearly described
csmall sample size, optimal information size not met