Table 4.
GRADE evidence table for the comparison combination of antibiotics vs. single drugs for children with Lyme neuroborreliosis
| Quality assessment | № of patients | Effect | Quality | ||||||
|---|---|---|---|---|---|---|---|---|---|
| № of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Combination of antibiotics | Single drugs | Relative (95 % CI) | |
| Neurological symptoms at last reported time point | |||||||||
| 1 | observational studies | very seriousa | not serious | seriousb | seriousc | 1/7 (14.3 %) | 2/2 (100.0 %) | RR 4.44 (0.96 to 20.50) | ⨁◯◯◯ VERY LOW |
acritical risk of bias according to ARCOBAT NRSI due to baseline confounding, selected patients, lack of blinding, interventions insufficiently described
bheterogeneous interventions applied
csmall sample size, optimal information size not met