Table 3.
Mood Ratings for Each Condition at Baseline and Following Completion of a Study Visit
| Placebo | MR Antagonist | GR Antagonist | ||||
|---|---|---|---|---|---|---|
| Baseline | Study Visit | Baseline | Study Visit | Baseline | Study Visit | |
| POMS Depressiona | 0.20 (0.42) | 0.10 (0.32) | 0.30 (0.95) | 0.10 (0.32) | 0.60 (1.35) | 0.40 (0.97) |
| POMS Totalb | -14.4 (7.82) | -11.0 (12.8) | -11.2 (14.5) | -8.00 (13.57) | -14.0 (8.03) | -11.5 (9.57) |
| STAI Statec | 23.8 (5.12) | 24.3 (1.72) | 24.3 (6.43) | 25.4 (5.91) | 24.5 (5.21) | 25.0 (4.37) |
| HDRSd | 0.80 (1.14) | 0.50 (0.97) | 0.70 (1.25) | |||
Abbreviations: HDRS = Hamilton Depression Rating Scale (21 item); POMS = Profile of Mood States; STAI = State/Trait Anxiety Inventory.
Numbers in parenthesis indicate 1 SDM.
a POMS depression subscale scores can range from 0 to 60, with higher scores indicating worsening depression.
b POMS Total mood disturbance scores can range from -32 to 200, with higher scores indicating worsening mood.
c STAI scores can range from 20 to 80, with higher scores indicating worsening anxiety.
d HDRS scores can range from 0 to 66, with higher scores indicating worsening clinical depression, and a score of 7 or greater indicating clinically significant depression.