Table 1.

The Stressors of a CMS Procedure

Stressor	Description	Duration (h)
Tilted caging	Each cage tilted to a 45-degree angle	18
Wet caging	200mL water in 100g sawdust bedding	12
Paired caging	Put mouse into cage of strange rat	12
Water/food deprivation	Deprivation water and food	12
Restraint stress	The mice are kept in closed and ventilated tubes	4
Intermittent illumination	2-h/2-h light/dark cycle	12
Continuous illumination	Continuous illumination in dark cycle	12