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. 2016 May 10;19(9):pyw046. doi: 10.1093/ijnp/pyw046

Figure 2.

Figure 2.

Monosialotetrahexosylganglioside (GM1) treatment reverses the chronic social defeat stress (CSDS)-induced decrease of brain derived neurotrophic factor (BDNF) signaling pathway in the hippocampus and medial prefrontal cortex (mPFC). (A) Western blot results showed that CSDS-susceptible + GM1 mice displayed significantly higher BDNF, pTrkB, pERK1/2, pAKT, and pCREB expression in the hippocampus than CSDS-susceptible + vehicle mice (n=6). (B) Parallel to the hippocampus data, CSDS-susceptible + GM1 mice also had significantly more BDNF, pTrkB, pERK1/2, pAKT, and pCREB expression in the mPFC compared with CSDS-susceptible + vehicle mice (n = 6). Data are expressed as the mean ± SEM; **P<.01 vs control; ## P<.01 vs CSDS susceptible + vehicle. Comparison was made by 2-way ANOVA followed by posthoc Bonferroni’s test.