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. 2016 May 10;19(9):pyw046. doi: 10.1093/ijnp/pyw046

Figure 4.

Figure 4.

K252a treatment antagonizes the effects of monosialotetrahexosylganglioside (GM1) on brain derived neurotrophic factor (BDNF) signaling cascade in the chronic social defeat stress (CSDS) model. (A) Western blot data revealed that CSDS-susceptible + GM1 + K252a mice displayed significantly lower BDNF, pTrkB, pERK1/2, pAKT, and pCREB expression in the hippocampus than CSDS-susceptible + GM1 mice (n = 6). (B) Similarly, western blot data showed that CSDS-susceptible + GM1 + K252a mice also had significantly lower BDNF, pTrkB, pERK1/2, pAKT, and pCREB expression in the medial prefrontal cortex (mPFC) than CSDS susceptible + GM1 mice (n = 6). Data are expressed as the mean ± SEM; ** P<.01 vs control; ## P<.01 vs CSDS-susceptible + vehicle. Comparison was made by 2-way ANOVA followed by posthoc Bonferroni’s test.