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. 2016 May 10;19(9):pyw046. doi: 10.1093/ijnp/pyw046

Figure 6.

Figure 6.

Anti-brain derived neurotrophic factor (BDNF) infusion blocks the effects of monosialotetrahexosylganglioside (GM1) on BDNF signaling pathway in the chronic social defeat stress (CSDS) model. (A) Western blot results showed that CSDS-susceptible + GM1 + anti-BDNF mice displayed significantly less BDNF, pTrkB, pERK1/2, pAKT, and pCREB expression in the hippocampus than CSDS-susceptible + GM1 mice (n = 5). (B) As in the hippocampus, western blot results indicated that the GM1-induced promotion of BDNF, pTrkB, pERK1/2, pAKT, and pCREB levels in the medial prefrontal cortex (mPFC) was also blocked by anti-BDNF antibody (n = 5). Data are expressed as the mean ± SEM; ** P<.01 vs control; ## P<.01 vs CSDS-susceptible + vehicle. Comparison was made by 2-way ANOVA followed by posthoc Bonferroni’s test.