Skip to main content
. 2016 May 6;19(9):pyw047. doi: 10.1093/ijnp/pyw047

Figure 1.

Figure 1.

Metformin improved motor behavior and increased catecholamine levels in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) mice. Time on rod was measured by rotarod test (a). Dopamine, dihydroxyphenylacetic acid, and homovanillic acid were analyzed by High Performance Liquid Chromatography (b). Data are presented as the mean ± SEM, n=8 for each group. Metformin prevented dopaminergic (DA) cells degeneration induced by MPTP plus probenecid (MPTP/p) in the midbrain. Immunohistochemical staining of TH-positive neurons in substania nigra compacta (SNc) of mice with ×40 magnifications (c). Stereological counts of Tyrosine hydroxylase-positive cells in mouse SNc (d). Data are presented as the mean±SEM, n=4 for each group. Scale bar, 200 μm. Evaluation of monoamine oxidase B activity of midbrain tissues (e), n=5 for each group. *P<.05, **P<.01, and ***P<.001 vs saline-treated mice. #P<.05 and ##P<.01 vs MPTP/p-treated mice. VTA, ventral tegmental area.